COVID-19 与系统性红斑狼疮中的免疫失调。
Dysregulation of immunity in COVID-19 and SLE.
机构信息
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Inflammopharmacology. 2022 Oct;30(5):1517-1531. doi: 10.1007/s10787-022-01047-2. Epub 2022 Aug 26.
The immune response plays a crucial role in preventing diseases, such as infections. There are two types of immune responses, specific and innate immunity, each of which consists of two components: cellular immunity and humoral immunity. Dysfunction in any immune system component increases the risk of developing certain diseases. Systemic lupus erythematosus (SLE), an autoimmune disease in the human body, develops an immune response against its own components. In these patients, due to underlying immune system disorders and receipt of immunosuppressive drugs, the susceptibility to infections is higher than in the general population and is the single largest cause of mortality in this group. COVID-19 infection, which first appeared in late 2019, has caused several concerns in patients with SLE. However, there is no strong proof of additional risk of developing COVID-19 in patients with SLE, and in some cases, studies have shown less severity of the disease in these individuals. This review paper discusses the immune disorders in SLE and COVID-19.
免疫反应在预防疾病（如感染）方面起着至关重要的作用。有两种类型的免疫反应，即特异性和先天性免疫，每种免疫反应都由细胞免疫和体液免疫两个部分组成。任何免疫系统成分的功能障碍都会增加某些疾病的发病风险。系统性红斑狼疮（SLE）是人体的一种自身免疫性疾病，会对自身成分产生免疫反应。在这些患者中，由于潜在的免疫系统紊乱和接受免疫抑制药物治疗，其感染易感性高于一般人群，是该人群死亡的单一最大原因。2019 年底首次出现的 COVID-19 感染引起了 SLE 患者的关注。然而，没有强有力的证据表明 SLE 患者患 COVID-19 的风险增加，在某些情况下，研究表明这些患者的疾病严重程度较低。本文综述了 SLE 和 COVID-19 中的免疫紊乱。
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