多个基因座与爱尔兰猎狼犬扩张型心肌病相关。
Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds.
机构信息
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany.
出版信息
PLoS One. 2012;7(6):e36691. doi: 10.1371/journal.pone.0036691. Epub 2012 Jun 25.
Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.
扩张型心肌病（DCM）是爱尔兰猎狼犬中一种高发且常致命的疾病。复杂分离分析表明，发病机制涉及不同的基因座。线性固定和混合模型用于全基因组关联研究。使用 106 例 DCM 病例和 84 例对照，我们在 CFA37 上鉴定出一个与 DCM 显著相关的 SNP，在 CFA1、10、15、21 和 17 上鉴定出五个与 DCM 呈暗示性相关的 SNP。在 CFA37 上，MOGAT1 和 ACSL3 两种脂质代谢酶位于鉴定出的 SNP 附近。
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