Department of Surgery, National Yang-Ming University Hospital, I-Lan, Taiwan.
PLoS One. 2012;7(6):e39264. doi: 10.1371/journal.pone.0039264. Epub 2012 Jun 22.
Few studies focus on pediatric spinal cord injury (SCI) and there is little information regarding the cause, anatomic level, and high risk population of SCI in children. This study aims to investigate the incidence and risk factors of pediatric SCI.
A nationwide cohort of 8.7 million children aged<18 years in an 11-year period was analyzed for causes, age at injury, anatomic sites, disability, and familial socio-economic factors. Incidence rates and Cox regression analysis were conducted.
A total of 4949 SCI patients were analyzed. The incidence rates of cervical, thoracic, lumbar, and other SCI were 4.06, 0.34, 0.75, and 0.85 per 100,000 person-years, respectively. The proportional composition of gender, age, and socio-economic status of SCI patients were significantly different than those of non-SCI patients (all p<0.001). Male children were significantly more likely to have SCI than females in both the cervical and the other SCI groups [Incidence rate ratio (IRR) = 2.03 and 1.52; both p<0.001]. Young adults and teenagers were also significantly more likely to have SCI than pre-school age children in the cervical SCI (IRR = 28.55 and 10.50, both p<0.001) and other SCI groups (IRR = 18.8 and 7.47, both p<0.001). Children in families of lower socio-economic status were also significantly more likely to have SCI (p<0.05).
In the pediatric population, the overall SCI incidence rate is 5.99 per 100,000 person-years, with traumatic cervical SCI accounting for the majority. The incidence rate increases abruptly in male teenagers. Gender, age, and socio-economic status are independent risk factors that should be considered.
鲜有研究关注儿科脊髓损伤（SCI），有关儿童 SCI 的病因、解剖部位和高危人群的信息也很少。本研究旨在调查儿科 SCI 的发病率和危险因素。
对一项为期 11 年的、年龄<18 岁的 870 万儿童的全国性队列进行了病因、损伤年龄、解剖部位、残疾和家族社会经济因素分析。进行了发病率和 Cox 回归分析。
共分析了 4949 例 SCI 患者。颈椎、胸椎、腰椎和其他 SCI 的发病率分别为 4.06、0.34、0.75 和 0.85/100,000 人年。SCI 患者的性别、年龄和社会经济地位的比例构成与非 SCI 患者明显不同（均 p<0.001）。男性儿童患颈椎和其他 SCI 的可能性明显高于女性（发病率比分别为 2.03 和 1.52；均 p<0.001）。与学龄前儿童相比，青年和青少年患颈椎 SCI（发病率比分别为 28.55 和 10.50；均 p<0.001）和其他 SCI 组（发病率比分别为 18.8 和 7.47；均 p<0.001）的可能性也显著更高。社会经济地位较低的家庭的儿童患 SCI 的可能性也明显更高（p<0.05）。
在儿科人群中，总体 SCI 发病率为 5.99/100,000 人年，以创伤性颈椎 SCI 为主。男性青少年的发病率急剧上升。性别、年龄和社会经济地位是独立的危险因素，应予以考虑。
