Adams P C, Frei J V, Bradley C, Lam D
Department of Medicine, Pathology and Clinical Biochemistry, University Hospital, University of Western Ontario, London.
Clin Invest Med. 1990 Oct;13(5):256-8.
The relationship between iron absorption and hepatic iron was studied in 21 patients with hemochromatosis. Iron absorption was studied using 59Fe and total body counting and hepatic iron was measured by atomic absorption spectrophotometry. Iron absorption was inversely related to hepatic iron concentration (r = -0.51, p = 0.009) in this patient population. This observation suggests that iron absorption is regulated by body iron stores even in hemochromatosis, and does not support the hypothesis that the primary metabolic defect in hemochromatosis is a deregulation of iron absorption in relation to iron stores.
对21例血色素沉着症患者的铁吸收与肝脏铁含量之间的关系进行了研究。采用59Fe和全身计数法研究铁吸收情况，并用原子吸收分光光度法测定肝脏铁含量。在该患者群体中，铁吸收与肝脏铁浓度呈负相关（r = -0.51，p = 0.009）。这一观察结果表明，即使在血色素沉着症中，铁吸收也受体内铁储存的调节，并不支持血色素沉着症的主要代谢缺陷是铁吸收相对于铁储存失调的假说。
