Batey R G, Pettit J E, Nicholas A W, Sherlock S, Hoffbrand A V
Gastroenterology. 1978 Nov;75(5):856-9.
Hepatic iron uptake from transferrin has been studied in 7 patients with treated hemochromatosis. When compared with a control group with similar serum iron and transferrin saturation the hemochromatotics had a significantly higher 4-hr iron uptake value. Uptake in the precirrhotic and cirrhotic hemochromatotics was not significantly different, suggesting the existence of a cellular abnormality of hepatic iron metabolism in this disease. The results provide an explanation for the development of siderosis in some patients with idiopathic hemochromatosis and a normal serum iron concentration.
对7例接受治疗的血色素沉着症患者肝脏从转铁蛋白摄取铁的情况进行了研究。与血清铁和转铁蛋白饱和度相似的对照组相比，血色素沉着症患者4小时铁摄取值显著更高。肝硬化前期和肝硬化期血色素沉着症患者的铁摄取无显著差异，提示该病存在肝脏铁代谢的细胞异常。这些结果为一些血清铁浓度正常的特发性血色素沉着症患者发生铁沉着症提供了解释。
