Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, USA.
J Otolaryngol Head Neck Surg. 2012 Jun 1;41(3):164-8.
To determine the usefulness of the VELscope in detecting malignant and premalignant oral cavity lesions.
Prospective clinical study.
Head and neck oncology clinic at an academic tertiary care centre.
Eighty-five patients with a history of smoking, alcohol use, and/or head and neck cancer were recruited into the study. The VELscope was used to examine patients' oral cavities after a clinical examination. Biopsies were then taken from suspicious areas.
Of the 85 patients included in the study, 33 underwent biopsies prompted by a clinical examination, the VELscope, or both. Biopsy results that showed invasive malignancy or dysplasias were considered positive. Five positive biopsies for premalignant lesions were detected only by the VELscope and were not visible on clinical examination. On the other hand, only one positive biopsy for a premalignant lesion was detected by the clinical examination only and not seen on the VELscope. Seven positive biopsies were detected by both methods. This indicates that the diagnostic yield from a regular examination was 47% (95% CI 23-72) and that the diagnostic yield from the addition of the VELscope was an additional 31% (95% CI 11-59). Sensitivity and specificity for the VELscope were 92% and 77%, respectively.
The Velscope may add sensitivity to the clinical examination and be a useful adjunct in high-risk patients.
确定 VELscope 在检测口腔恶性和癌前病变中的作用。
前瞻性临床研究。
学术性三级护理中心的头颈肿瘤诊所。
招募了 85 名有吸烟、饮酒和/或头颈部癌症史的患者参与研究。VELscope 用于检查患者的口腔，然后从可疑区域进行活检。
在纳入研究的 85 名患者中，33 名患者因临床检查、VELscope 或两者而接受了活检。活检结果显示浸润性恶性肿瘤或发育不良被认为是阳性。VELscope 仅检测到 5 例癌前病变的阳性活检，而临床检查则无法发现。另一方面，只有一例癌前病变的阳性活检仅通过临床检查发现，VELscope 上则未显示。两种方法均检测到 7 例阳性活检。这表明常规检查的诊断率为 47%（95%CI 23-72%），而 VELscope 的附加检查诊断率为 31%（95%CI 11-59%）。VELscope 的敏感性和特异性分别为 92%和 77%。
VELscope 可能会提高临床检查的敏感性，并且是高危患者的有用辅助手段。
