Upper Airway Research Laboratory (URL), Department of Oto-Rhino-Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium.
Pediatr Allergy Immunol. 2012 Aug;23 Suppl 22:2-4. doi: 10.1111/j.1399-3038.2012.01318.x.
Chronic rhinosinusitis (CRS) has now been discovered as a frequent disease affecting about 11% of the European population. In clinical terms, CRS may be differentiated in two phenotypes, CRS with and without nasal polyps. This differentiation is also confirmed by immunohistochemical studies on the remodeling pattern of those diseases, identifying TGF-ß as the key regulator. Further differentiation may be based on the inflammatory patterns, differentiating endotypes based on prominent T helper cell cytokines such as interleukin-5 and the presence of IgE antibodies against Staphylococcus aureus enterotoxins. The importance of those endotypes has been confirmed by innovative studies using humanized antibodies applied to nasal polyp disease, and by their predictive value for asthma comorbidity. Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma.
慢性鼻-鼻窦炎（CRS）现已被发现是一种常见疾病，影响约 11%的欧洲人口。临床上，CRS 可分为两种表型，即伴有和不伴有鼻息肉的 CRS。这种分化也得到了对这些疾病重塑模式的免疫组织化学研究的证实，鉴定 TGF-β为关键调节因子。进一步的分化可能基于炎症模式，根据突出的 T 辅助细胞细胞因子（如白细胞介素-5）和针对金黄色葡萄球菌肠毒素的 IgE 抗体的存在，区分内型。使用针对鼻息肉疾病的人源化抗体进行的创新性研究以及它们对哮喘合并症的预测价值，证实了这些内型的重要性。因此，可能需要生物标志物来充分了解 CRS 疾病谱及其与哮喘的关系。
