Department of Exercise Science, University of South Carolina, Columbia, SC 29208, USA.
Ann Epidemiol. 2012 Sep;22(9):617-22. doi: 10.1016/j.annepidem.2012.05.005. Epub 2012 Jul 3.
We modeled the age-related trajectory of glucose and determined whether cardiorespiratory fitness altered the trajectory in a cohort of men from the Aerobics Center Longitudinal Study.
A total of 10,092 men free of diagnosed diabetes, cardiovascular disease, and cancer, ages 20 to 90 years, completed from 2 to 21 health examinations between 1977 and 2005. Cardiorespiratory fitness was measured by a maximal treadmill exercise test and normalized for age. The covariates included waist circumference, hypertension, elevated cholesterol, smoking behavior, and physical activity.
Linear mixed models regression analysis showed that fasting glucose increased at a linear rate with aging. Glucose increased at a yearly rate of 0.17 mg/dL (95% confidence interval: 0.16-0.19). Fitness had little influence on the aging glucose trajectory below age 35, but significantly influenced the trend after age 35 (P for interaction < .001). The aging-related glucose increases in low-fitness men (0.25 mg/dL per year) was greater than average-fitness (0.15 mg/dL per year) and high-fitness (0.13 mg/dL per year) men.
The aging-related fasting glucose increases in low-fitness men was nearly double that of high-fitness men. Our results may suggest that it is possible to delay the age-related glucose impairment through increasing one's fitness level.
我们构建了葡萄糖与年龄相关的轨迹模型，并在一项来自有氧运动中心纵向研究的男性队列中，确定了心肺适能是否改变了这一轨迹。
共有 10092 名年龄在 20 至 90 岁之间、无糖尿病、心血管疾病和癌症诊断的男性参加了这项研究，他们在 1977 年至 2005 年间完成了 2 至 21 次健康检查。心肺适能通过最大跑步机运动测试进行测量，并按年龄进行标准化。协变量包括腰围、高血压、胆固醇升高、吸烟行为和体力活动。
线性混合模型回归分析显示，空腹血糖随年龄呈线性增长。血糖每年增加 0.17 毫克/分升（95%置信区间：0.16-0.19）。在 35 岁以下，心肺适能对衰老相关的血糖轨迹影响不大，但在 35 岁后，这种趋势有显著影响（交互作用 P<0.001）。低心肺适能男性（每年增加 0.25 毫克/分升）的衰老相关血糖升高高于平均心肺适能（每年增加 0.15 毫克/分升）和高心肺适能（每年增加 0.13 毫克/分升）男性。
低心肺适能男性与年龄相关的空腹血糖升高几乎是高心肺适能男性的两倍。我们的研究结果表明，通过提高一个人的心肺适能水平，有可能延缓与年龄相关的血糖损害。
