Department of Aerospace Engineering, Indian Institute of Science, Bangalore, India.
Appl Microbiol Biotechnol. 2012 Nov;96(3):647-62. doi: 10.1007/s00253-012-4196-8. Epub 2012 Jul 5.
Small quantity of energetic material coated on the inner wall of a polymer tube is proposed as a new method to generate micro-shock waves in the laboratory. These micro-shock waves have been harnessed to develop a novel method of delivering dry particle and liquid jet into the target. We have generated micro-shock waves with the help of reactive explosive compound [high melting explosive (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) and traces of aluminium] coated polymer tube, utilising ∼9 J of energy. The detonation process is initiated electrically from one end of the tube, while the micro-shock wave followed by the products of detonation escape from the open end of the polymer tube. The energy available at the open end of the polymer tube is used to accelerate tungsten micro-particles coated on the other side of the diaphragm or force a liquid jet out of a small cavity filled with the liquid. The micro-particles deposited on a thin metal diaphragm (typically 100-μm thick) were accelerated to high velocity using micro-shock waves to penetrate the target. Tungsten particles of 0.7 μm diameter have been successfully delivered into agarose gel targets of various strengths (0.6-1.0 %). The device has been tested by delivering micro-particles into potato tuber and Arachis hypogaea Linnaeus (ground nut) stem tissue. Along similar lines, liquid jets of diameter ∼200-250 μm (methylene blue, water and oils) have been successfully delivered into agarose gel targets of various strengths. Successful vaccination against murine salmonellosis was demonstrated as a biological application of this device. The penetration depths achieved in the experimental targets are very encouraging to develop a future device for biological and biomedical applications.
提出了一种在聚合物管内壁涂覆少量高能材料的新方法，以在实验室中产生微激波。已经利用这些微激波开发了一种将干颗粒和液体射流输送到目标的新方法。我们利用涂覆有反应性爆炸化合物（高熔点炸药（八氢-1,3,5,7-四硝基-1,3,5,7-四唑）和微量铝）的聚合物管产生微激波，利用约 9 J 的能量。爆炸过程从管的一端电引发，而微激波随后伴随着爆炸产物从聚合物管的开口端逸出。聚合物管开口端的能量可用于加速涂覆在隔膜另一侧的钨微颗粒，或迫使充满液体的小腔中的液体射流流出。使用微激波将沉积在薄金属膜（通常为 100-μm 厚）上的微颗粒加速到高速，以穿透目标。已经成功地将直径为 0.7μm 的钨颗粒输送到各种强度（0.6-1.0%）的琼脂糖凝胶目标中。该装置已通过将微颗粒输送到马铃薯块茎和花生（落花生）茎组织中进行了测试。类似地，直径约为 200-250μm 的甲基蓝、水和油等液体射流已成功输送到各种强度的琼脂糖凝胶目标中。作为该装置的生物应用，成功地对鼠伤寒沙门氏菌进行了疫苗接种。在实验目标中实现的穿透深度非常令人鼓舞，为开发用于生物和生物医学应用的未来装置奠定了基础。
