Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA.
Sci Transl Med. 2012 Jul 4;4(141):141ps13. doi: 10.1126/scitranslmed.3004261.
Recent insights into circulating tumor cells (CTCs) have been driven by numerous technological innovations aimed at isolating, purifying, and analyzing these rare cells. However, the information density within these cells has yet to be truly accessed and exploited for patient benefit. A device reported by Issadore et al. in this issue of Science Translational Medicine proposes a highly sensitive methodology that may both extend CTC capture to a broader patient population and provide greater understanding of biological targets for personalized medical therapies.
最近，许多旨在分离、纯化和分析这些稀有细胞的技术创新推动了对循环肿瘤细胞（CTC）的深入了解。然而，这些细胞内的信息密度尚未真正被获取和利用，以造福患者。伊萨多尔等人在本期《科学转化医学》中报道的一种设备提出了一种高度敏感的方法，该方法可能既可以将 CTC 的捕获扩展到更广泛的患者群体，又可以更深入地了解个性化医疗疗法的生物学靶点。
