比较囊型包虫病致过敏性休克患者与非过敏性休克患者血清总 IgE、IgG 和 IgG1 水平。
Comparisons of serum total IgE, IgG, and IgG1 levels in patients with and without echinococcosis-induced anaphylactic shock.
机构信息
Department of Pain Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
出版信息
Am J Trop Med Hyg. 2012 Jul;87(1):104-8. doi: 10.4269/ajtmh.2012.11-0694.
We investigated serum total immunoglobulin E (IgE), IgG, and IgG1 levels in patients with and without echinococcosis-induced anaphylactic shock. This was a case-control study of 11 patients with echinococcosis-induced anaphylactic shock and 22 echinococcosis patients with cyst rupture but without anaphylactic shock. Blood was collected before surgery (T0), at the time of cyst rupture (T1), and shock (Tx), 1 h (T2), 1 day (T3), and 1 week (T4) after cyst rupture. Serum IgE, IgG, and IgG1 were determined by enzyme-linked immunosorbent assay. Serum IgE, IgG, and IgG1 levels were significantly higher in patients who developed anaphylactic shock at all time points. Increased pre-surgical IgG and IgG1 levels were identified to be a significant risk factors for developing anaphylactic shock. The results showed that a serum IgG concentration of 312.25 μg/mL could be used as a cut-off point to predict whether an echinococcosis patient would develop anaphylactic shock.
我们研究了伴有和不伴有包虫病性过敏性休克的患者血清总免疫球蛋白 E（IgE）、IgG 和 IgG1 水平。这是一项对 11 例包虫病性过敏性休克患者和 22 例包虫病囊肿破裂但无过敏性休克患者的病例对照研究。血液采集于术前（T0）、囊肿破裂时（T1）、休克时（Tx）、破裂后 1 小时（T2）、1 天（T3）和 1 周（T4）。采用酶联免疫吸附试验测定血清 IgE、IgG 和 IgG1。在所有时间点，发生过敏性休克的患者血清 IgE、IgG 和 IgG1 水平显著升高。术前 IgG 和 IgG1 水平升高被确定为发生过敏性休克的显著危险因素。结果表明，血清 IgG 浓度为 312.25μg/mL 可作为预测包虫病患者是否发生过敏性休克的临界点。
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