Hemet J, Laquerrière A, Lemoine F, Doublet B, Metayer J
Laboratoire d'Anatomie Pathologique, CHU Charles-Nicolle, Rouen.
Gastroenterol Clin Biol. 1990;14(11):873-6.
Carcinoma complicating ulcerative colitis, although an uncommon event, is well known but follow-up of patients to detect high-grade dysplasia as a potential indicator for colectomy is very difficult. Retrospective morphological and cytometrical analysis of three resected colons harboring carcinoma coming from patients with ulcerative colitis were performed. It allowed to confirm the value of this technique. Histogram patterns varied between narrow unimodal in quiescent mucosa to broad unimodal with high IP (proliferation index) in regenerative mucosa and aneuploid in high dysplasic mucosa and carcinoma. In addition to histopathology and in spite of a patchy distribution of aneuploidy, different degrees of dysplasia in mucosa and technical sensibility DNA (desoxyribonucleic acid) analysis in long-standing ulcerative colitis seems to be helpful in the detection of potential malignancy.
癌合并溃疡性结肠炎虽不常见，但广为人知，然而对患者进行随访以检测高级别异型增生作为结肠切除术的潜在指标却非常困难。对3例来自溃疡性结肠炎患者的结肠癌切除结肠进行了回顾性形态学和细胞计量学分析。这证实了该技术的价值。直方图模式在静止黏膜中为窄单峰，在再生黏膜中为宽单峰且增殖指数高，在高度异型增生黏膜和癌中为非整倍体。除了组织病理学外，尽管非整倍体呈斑片状分布，但黏膜不同程度的异型增生以及长期溃疡性结肠炎中的技术敏感性DNA（脱氧核糖核酸）分析似乎有助于检测潜在恶性肿瘤。
