血管活性药物对人胎盘血管平滑肌的作用。

Actions of vasoactive drugs on human placental vascular smooth muscle.

Reviriego J, Fernandez-Alfonso M S, Marín J

Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad de Extremadura, Madrid, Spain.

Gen Pharmacol. 1990;21(5):719-27. doi: 10.1016/0306-3623(90)91024-l.

Abstract

The effect of different vasoactive agents on segments of human chorionic arteries and veins was analyzed. 2. The order of these agents to produce maximal contractile responses was: 5-hydroxytryptamine (5-HT) = histamine (H) = K+ greater than noradrenaline (NA) greater than or equal to phenylephrine (PHEN) greater than clonidine (CLON), and with regard to their potencies (EC50 values) was: 5-HT greater than or equal to NA greater than or equal to H greater than PHEN greater than CLON greater than K+. Dopamine and isoproterenol did not elicit any type of response. 3. The receptors involved on the contractions elicited by agonists were analyzed. 4. The results obtained suggest that: (1) 5-HT is the most potent vasoconstrictor agent of all those tested, whose effects appear to be mediated by 5-HT2- but not by alpha 1-adrenergic receptors; (2) chorionic vessels also possess H1-receptors; and (3) ketanserin has more affinity to block 5-HT2-receptors than to block alpha 1-adrenergic- and H1-receptors.

摘要

分析了不同血管活性药物对人绒毛膜动脉和静脉段的作用。2. 这些药物产生最大收缩反应的顺序为：5-羟色胺（5-HT）=组胺（H）=钾离子（K⁺）＞去甲肾上腺素（NA）≥苯肾上腺素（PHEN）＞可乐定（CLON），就其效力（半数有效浓度值）而言为：5-HT≥NA≥H＞PHEN＞CLON＞K⁺。多巴胺和异丙肾上腺素未引发任何类型的反应。3. 分析了激动剂引发收缩所涉及的受体。4. 所得结果表明：（1）5-HT是所有测试药物中最有效的血管收缩剂，其作用似乎由5-HT₂受体介导，而非α₁肾上腺素能受体；（2）绒毛膜血管也具有H₁受体；（3）酮色林阻断5-HT₂受体的亲和力高于阻断α₁肾上腺素能受体和H₁受体。