肠致病性大肠杆菌（EPEC）产生的细胞致死性膨胀毒素（CLDT）
Cytolethal distending toxin (CLDT) production by enteropathogenic Escherichia coli (EPEC).
作者信息
Bouzari S, Varghese A
机构信息
Department of Microbiology, Maulana Azad Medical College, New Delhi, India.
出版信息
FEMS Microbiol Lett. 1990 Sep 1;59(1-2):193-8. doi: 10.1016/0378-1097(90)90055-u.
Culture supernates of 16 strains of EPEC belonging to 6 different serogroups, when assayed on Chinese Hamster Ovary (CHO) cells up to 96-120 h, induced distinct morphological changes. The supernate activities were heat-labile, unrelated to heat-labile enterotoxin (LT), verotoxin (VT), or hemolysin, did not show necrosis in rabbit skin and caused no fluid secretion in the rabbit ileal loop assay (RILA). Simultaneous production of CLDT and heat-stable enterotoxin (ST) were detected in four EPEC strains.
对属于6个不同血清群的16株肠致病性大肠杆菌（EPEC）的培养上清液，在中国仓鼠卵巢（CHO）细胞上检测长达96 - 120小时时，可诱导明显的形态学变化。上清液活性不耐热，与不耐热肠毒素（LT）、志贺毒素（VT）或溶血素无关，在兔皮试验中未显示坏死，在兔回肠袢试验（RILA）中未引起液体分泌。在4株EPEC菌株中检测到同时产生细胞致死性膨胀毒素（CLDT）和耐热肠毒素（ST）。
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