氯仿的致癌性。
Carcinogenicity of chloroform.
作者信息
Reuber M D
出版信息
Environ Health Perspect. 1979 Aug;31:171-82. doi: 10.1289/ehp.7931171.
Abstract
Chloroform is carcinogenic in rats, mice, and probably in dogs. Chloroform induced carcinomas of the liver and kidney and malignant tumors in other organs in rats and mice. Liver neoplasms have been described in three strains of mice. Carcinomas of the kidney were found in a first study in mice and in the repeat of that study. Dogs given chloroform developed neoplasms of the liver as well as in other organs. Rats given chloroform also developed toxic changes, particularly male rats, as a result of treatment. These lesions included interstitial fibrosis of the kidney; polyarteritis of the mesenteric, pancreatic, and other arterioles and arteries; and atrophy of the testes. These toxic changes may have interfered with the development of neoplasms in male rats.
摘要
氯仿对大鼠、小鼠甚至可能对狗都具有致癌性。氯仿可诱发大鼠和小鼠的肝癌、肾癌以及其他器官的恶性肿瘤。在三种品系的小鼠中均发现了肝脏肿瘤。在对小鼠的首次研究及其重复实验中均发现了肾癌。给狗施用氯仿后，其肝脏以及其他器官出现了肿瘤。给大鼠施用氯仿后，由于治疗还出现了毒性变化，尤其是雄性大鼠。这些病变包括肾间质纤维化；肠系膜、胰腺和其他小动脉及动脉的多动脉炎；以及睾丸萎缩。这些毒性变化可能干扰了雄性大鼠肿瘤的发生。
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