Forsythe Paul, Bienenstock John
The Brain-Body Institute, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, Ont., Canada.
Chem Immunol Allergy. 2012;98:196-221. doi: 10.1159/000336523. Epub 2012 Jun 26.
A key characteristic of mast cells appears to be an ability to span the division between nervous and immune system. Indeed, much of our understanding of the bi-directional relationship between the nervous and immune systems has come from the study of mast cell-nerve interaction. Although differences in species have been reported, morphologic as well as functional associations between mast cell and nerves are found in most tissues in many mammalian species, including humans. These interactions are involved in the regulation of physiologic homeostatic processes as well as in disease mechanisms. Here we discuss the influence of cholinergic and sensory neurons on mast cells as well as the importance of mast cell nerve interactions at specific tissue sites, including the brain.
肥大细胞的一个关键特征似乎是能够跨越神经和免疫系统之间的界限。事实上，我们对神经和免疫系统之间双向关系的许多理解都来自对肥大细胞与神经相互作用的研究。尽管不同物种之间存在差异的报道，但在包括人类在内的许多哺乳动物的大多数组织中，都发现了肥大细胞与神经之间的形态学以及功能上的联系。这些相互作用参与生理稳态过程的调节以及疾病机制。在这里，我们讨论胆碱能神经元和感觉神经元对肥大细胞的影响，以及肥大细胞与神经在特定组织部位（包括大脑）相互作用的重要性。
