痒觉的转化研究。
The translational revolution of itch.
机构信息
Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Neuron. 2022 Jul 20;110(14):2209-2214. doi: 10.1016/j.neuron.2022.03.031. Epub 2022 Apr 20.
Abstract
The ability to sense the environment is essential to survival and is the primary purpose of the somatosensory nervous system. However, despite its highly conserved nature, the sensation of itch has been historically overlooked, and its importance in medicine underappreciated. Herein, we highlight how fundamental discoveries, coupled to rapid successes of new therapeutics, have placed itch biology at the forefront of a translational revolution in the field of somatosensation and beyond.
摘要
感知环境的能力对于生存至关重要，也是躯体感觉神经系统的主要目的。然而，尽管它具有高度的保守性，但瘙痒感在历史上一直被忽视，其在医学中的重要性也未被充分认识。在此，我们强调了基本发现是如何结合新型疗法的快速成功，使瘙痒生物学成为躯体感觉领域乃至更广泛领域转化研究革命的前沿。
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本文引用的文献
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J Allergy Clin Immunol. 2022 Sep;150(3):690-700. doi: 10.1016/j.jaci.2022.01.028. Epub 2022 Mar 1.
2
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors.背根神经节的空间转录组学鉴定出人类伤害感受器的分子特征。
Sci Transl Med. 2022 Feb 16;14(632):eabj8186. doi: 10.1126/scitranslmed.abj8186.
3
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons.人类背根神经节神经元的单细胞转录组分析。
Elife. 2021 Nov 26;10:e71752. doi: 10.7554/eLife.71752.
4
Structure, function and pharmacology of human itch receptor complexes.人瘙痒受体复合物的结构、功能和药理学。
Nature. 2021 Dec;600(7887):164-169. doi: 10.1038/s41586-021-04077-y. Epub 2021 Nov 17.
5
Structure, function and pharmacology of human itch GPCRs.人类瘙痒 G 蛋白偶联受体的结构、功能和药理学。
Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17.
6
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