Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neuron. 2022 Jul 20;110(14):2209-2214. doi: 10.1016/j.neuron.2022.03.031. Epub 2022 Apr 20.
The ability to sense the environment is essential to survival and is the primary purpose of the somatosensory nervous system. However, despite its highly conserved nature, the sensation of itch has been historically overlooked, and its importance in medicine underappreciated. Herein, we highlight how fundamental discoveries, coupled to rapid successes of new therapeutics, have placed itch biology at the forefront of a translational revolution in the field of somatosensation and beyond.
感知环境的能力对于生存至关重要，也是躯体感觉神经系统的主要目的。然而，尽管它具有高度的保守性，但瘙痒感在历史上一直被忽视，其在医学中的重要性也未被充分认识。在此，我们强调了基本发现是如何结合新型疗法的快速成功，使瘙痒生物学成为躯体感觉领域乃至更广泛领域转化研究革命的前沿。
