卡介苗（BCG）免疫疗法治疗膀胱癌伴发的SAPHO综合征
SAPHO syndrome with bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer.
作者信息
Matsumaru Katsuhiko, Nagai Kazuki, Murakami Takayuki, Andoh Kazuo
机构信息
Department of Internal Medicine, Nagai Clinic, Yokohama, Japan.
出版信息
BMJ Case Rep. 2010 Aug 31;2010:2591. doi: 10.1136/bcr.12.2009.2591.
Abstract
The authors describe a case of SAPHO syndrome with bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer. The patient had undergone transurethral resection (TUR) and was treated with BCG immunotherapy following TUR. Two years after treatment for bladder cancer, the patient had palmoplantar pustulosis, and in the past 1 month suffered from pain localised to the anterior chest wall. The bone scintigraphy showed a strong focal enrichment in the right chest wall, suggesting spondyloarthropathy rather than malignant disease. On the basis of clinical and scintigraphy findings, SAPHO syndrome was diagnosed. The patient was treated with topical therapy and non-steroidal anti-inflammatory drugs and symptoms improved. The authors suggest that SAPHO syndrome might be caused by an association with BCG immunotherapy.
摘要
作者描述了一例患有卡介苗（BCG）免疫疗法治疗膀胱癌后出现SAPHO综合征的病例。该患者接受了经尿道切除术（TUR），并在TUR后接受了BCG免疫疗法。膀胱癌治疗两年后，患者出现掌跖脓疱病，且在过去1个月中前胸壁局部疼痛。骨闪烁显像显示右胸壁有强烈的局灶性浓聚，提示为脊柱关节病而非恶性疾病。根据临床和闪烁显像结果，诊断为SAPHO综合征。患者接受了局部治疗和非甾体抗炎药治疗，症状有所改善。作者认为，SAPHO综合征可能与BCG免疫疗法有关。
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