Department of Periodontology, Tokyo Dental College, Chiba, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Aug;114(2):e14-21. doi: 10.1016/j.oooo.2011.09.012. Epub 2012 Mar 3.
The aim of this study was to investigate the effect of basic fibroblast growth factor (FGF-2) on root resorption after delayed autotransplantation in dogs.
Mandibular second and third premolars of beagle dogs were extracted to create sites for autotransplantation. After 2 months, in the experimental sites the first and fourth mandibular premolars were extracted and air dried before autotransplantation with the application of recombinant FGF-2; the control sites received teeth without FGF-2. At 2, 4, or 8 weeks after surgery, the animals were killed and specimens collected and processed for histologic examination.
Autotransplantation with FGF-2 yielded formation of new periodontal ligament-like tissues with inserting collagen fibers, associated cementum, and bone. The occurrence of replacement resorption in the FGF-2 treated group was significantly lower than in the control group (P < .01).
It was demonstrated that topical application of FGF-2 reduced the occurrence of ankylosis and root resorption after delayed autotransplantation in this experimental model.
本研究旨在探讨碱性成纤维细胞生长因子（FGF-2）对犬延迟自体移植后牙根吸收的影响。
从比格犬下颌第二和第三前磨牙中提取以创建自体移植部位。2 个月后，在实验部位，第一和第四下颌前磨牙被提取并风干，然后应用重组 FGF-2 进行自体移植；对照部位接受未应用 FGF-2 的牙齿。手术后 2、4 或 8 周，处死动物并采集标本进行组织学检查。
FGF-2 自体移植后形成了具有插入胶原纤维、相关牙骨质和骨的新牙周韧带样组织。在 FGF-2 处理组中，发生替代性吸收的情况明显低于对照组（P<0.01）。
在该实验模型中，局部应用 FGF-2 可减少延迟自体移植后发生的粘连和牙根吸收。
