Mona Mahmoud, Abbasi Zunnaira, Kobeissy Firas, Chahbandar Abdulrahman, Pileggi Roberta
Department of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Department of Emergency Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Int J Mol Sci. 2021 Mar 20;22(6):3181. doi: 10.3390/ijms22063181.
External root resorption (ERR) is a silent destructive phenomenon detrimental to dental health. ERR may have multiple etiologies such as infection, inflammation, traumatic injuries, pressure, mechanical stimulations, neoplastic conditions, systemic disorders, or idiopathic causes. Often, if undiagnosed and untreated, ERR can lead to the loss of the tooth or multiple teeth. Traditionally, clinicians have relied on radiographs and cone beam computed tomography (CBCT) images for the diagnosis of ERR; however, these techniques are not often precise or definitive and may require exposure of patients to more ionizing radiation than necessary. To overcome these shortcomings, there is an immense need to develop non-invasive approaches such as biomarker screening methods for rapid and precise diagnosis for ERR. In this review, we performed a literature survey for potential salivary or gingival crevicular fluid (GCF) proteomic biomarkers associated with ERR and analyzed the potential pathways leading to ERR. To the best of our knowledge, this is the first proteomics biomarker survey that connects ERR to body biofluids which represents a novel approach to diagnose and even monitor treatment progress for ERR.
外部牙根吸收（ERR）是一种对牙齿健康有害的隐匿性破坏现象。ERR可能有多种病因，如感染、炎症、外伤、压力、机械刺激、肿瘤性疾病、全身性疾病或特发性原因。通常，如果未被诊断和治疗，ERR会导致一颗或多颗牙齿脱落。传统上，临床医生依靠X线片和锥形束计算机断层扫描（CBCT）图像来诊断ERR；然而，这些技术往往不够精确或具有决定性，而且可能会让患者接受不必要的更多电离辐射。为了克服这些缺点，迫切需要开发非侵入性方法，如生物标志物筛查方法，以快速、精确地诊断ERR。在本综述中，我们对与ERR相关的潜在唾液或龈沟液（GCF）蛋白质组学生物标志物进行了文献调查，并分析了导致ERR的潜在途径。据我们所知，这是首次将ERR与人体生物流体联系起来的蛋白质组学生物标志物调查，这代表了一种诊断ERR甚至监测其治疗进展的新方法。
