Kondo H, Nakajima S, Yamamoto N, Okura A, Satoh F, Suda H, Okanishi M, Tanaka N
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1990 Dec;43(12):1533-42. doi: 10.7164/antibiotics.43.1533.
Streptomyces graminofaciens BA14348, isolated from a soil sample, was found to produce new specific inhibitors of estrogen binding to its receptor. Five related substances, BE-14348A approximately E, were isolated, and their structures were determined by analyses of spectral properties. Of these substances, A was identical with the known flavanone, naringenin. On the other hand, B, C, D and E were all new compounds; the structure of B was determined to be 2(S): 3(S)-3-methyl-4',5,7-trihydroxyflavanone, C was a racemic mixture of 2(S): 3 (R) and 2(R): 3(S)-3-methyl-4',5,7-trihydroxyflavanone; D and E were 8-chloro derivatives of B and C, respectively.
从土壤样品中分离出的禾本科链霉菌BA14348被发现能产生雌激素与其受体结合的新型特异性抑制剂。分离出了5种相关物质，即BE-14348A至E，并通过光谱性质分析确定了它们的结构。在这些物质中，A与已知的黄烷酮柚皮素相同。另一方面，B、C、D和E均为新化合物；B的结构确定为2(S):3(S)-3-甲基-4',5,7-三羟基黄烷酮，C是2(S):3(R)和2(R):3(S)-3-甲基-4',5,7-三羟基黄烷酮的外消旋混合物；D和E分别是B和C的8-氯衍生物。
