Department of Neurodegenerative Diseases, Institute of Neurology, University College London, London WC1N 3BG, UK.
Newcastle University, Wolfson Research Center, Institute of Ageing & Health, Newcastle Upon Tyne NE4 5PL, UK.
Alzheimers Res Ther. 2012 Jul 6;4(4):23. doi: 10.1186/alzrt126. eCollection 2012.
Clinical research is best done when aligned with clinical care - that is, when the patient can be identified, recruited and, in many instances, researched in parallel with the delivery of clinical service. However, to achieve this effectively requires identification of the additional cost to the National Health Service clinical support services and the development of an appropriately skilled workforce. The National Institute for Health Research (NIHR) Cancer Research Network demonstrated the value of dedicated research support in terms of the number of patients recruited into clinical trials. Building on this model, the NIHR in England funded the Dementias and Neurodegenerative Diseases Research Network (DeNDRoN). DeNDRoN is now in its sixth year and has established a geographically widespread network of research support staff and research leadership managed by a central coordinating centre. Success can already be measured by a significant increase in the number of patients entering studies and the speed with which both commercial and noncommercial studies are completed. There are also early indications that the network will result in improved patient outcomes.
临床研究与临床护理最好是一致的——也就是说，当患者可以被识别、招募，并且在许多情况下，与临床服务同时进行研究时。然而，要有效地实现这一目标，需要确定对国家卫生服务临床支持服务的额外成本，并培养一支具备适当技能的劳动力队伍。国家卫生研究院（NIHR）癌症研究网络展示了专门研究支持在招募临床试验患者数量方面的价值。在此基础上，英国国家卫生研究院（NIHR）为痴呆症和神经退行性疾病研究网络（DeNDRoN）提供资金。DeNDRoN 现已进入第六个年头，建立了一个由中央协调中心管理的、在地理上广泛分布的研究支持人员和研究领导网络。通过进入研究的患者数量的显著增加以及商业和非商业研究的完成速度，可以衡量出成功。也有早期迹象表明，该网络将改善患者的预后。
