Centre for Genomic Regulation (CRG) and UPF, Dr. Aiguader 88, 08003 Barcelona, Spain.
Cell Stem Cell. 2012 Jul 6;11(1):16-21. doi: 10.1016/j.stem.2012.06.005.
Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.
多梳抑制复合物蛋白（PcGs）生成组蛋白修饰复合物，调控基因表达。PcGs 可分为两类：多梳抑制复合物 1（PRC1）和 2（PRC2），它们被认为经典地协同发挥作用。本文讨论了挑战该模型的最新数据，表明 PRC1 的独特亚基组成赋予了胚胎和成人干细胞中特定且不重叠的功能。
