Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL,USA.
Transcription. 2022 Feb-Jun;13(1-3):82-87. doi: 10.1080/21541264.2022.2105128. Epub 2022 Jul 29.
Transcription regulation is an important mechanism that controls pluripotency and differentiation. Transcription factors dictate cell fate decisions by functioning cooperatively with chromatin regulators. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein regulates the expression of differentiation-associated genes by modulating the chromatin architecture at promoters. We highlight the collaboration of BEND3 with the polycomb repressive complex in coordinating transcription repression and propose a model highlighting the relevance of the BEND3-PRC2 axis in gene regulation and chromatin organization. BEND3, BANP, E5R and Nac1 domain; rDNA, ribosomal DNA; PRC2, Repressive Complex 2; H3K27me3, Histone H3 Lysine 27 methylation; PcG, Polycomb group.
转录调控是一种重要的机制，它可以控制多能性和分化。转录因子通过与染色质调节剂协同作用来决定细胞命运。我们最近证明，BEND3（BANP、E5R 和 Nac1 结构域）蛋白通过调节启动子处的染色质结构来调节分化相关基因的表达。我们强调了 BEND3 与多梳抑制复合物在协调转录抑制方面的协作，并提出了一个模型，突出了 BEND3-PRC2 轴在基因调控和染色质组织中的相关性。BEND3、BANP、E5R 和 Nac1 结构域；rDNA，核糖体 DNA；PRC2，抑制复合物 2；H3K27me3，组蛋白 H3 赖氨酸 27 甲基化；PcG，多梳组。
