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胃束带术和袖状胃切除术术后正常的酒精代谢:病例交叉试验。

Normal alcohol metabolism after gastric banding and sleeve gastrectomy: a case-cross-over trial.

机构信息

Mount Sinai Hospital, Chicago, IL, USA.

出版信息

J Am Coll Surg. 2012 Oct;215(4):475-9. doi: 10.1016/j.jamcollsurg.2012.06.008. Epub 2012 Jul 6.

DOI:10.1016/j.jamcollsurg.2012.06.008
PMID:22770864
Abstract

BACKGROUND

Severe obesity remains the leading public health concern of the industrialized world, with bariatric surgery as the only current effective enduring treatment. In addition to gastric bypass, gastric banding and sleeve gastrectomy have emerged as viable treatment options for the severely obese. Occasionally, poor postoperative psychological adjustment has been reported. It has been previously demonstrated that breath alcohol content (BAC) levels and time to sober were increased in postoperative gastric bypass patients. The aim of this study was to examine whether alcohol metabolism in patients undergoing restrictive-type bariatric procedures is also altered.

STUDY DESIGN

Nine patients undergoing laparoscopic adjustable gastric banding (LAGB) and 7 patients undergoing laparoscopic sleeve gastrectomy (LSG) were recruited. Preoperatively, 3-month and 6-month BAC and time to sober were measured after administration of 5 ounces of red wine. In addition, participants were asked to complete a questionnaire of drinking habits.

RESULT

The 16 total participants achieved a mean 44.7% 6-month excess weight loss. There were no significant changes in peak BAC or time to sober from preoperative levels (0.033%, 67.8 min, respectively) to 3 months (0.032%, 77.1 min, respectively, p = 0.421) or 6 months (0.035%, 81.2 min, respectively, p = 0.198).

CONCLUSION

Patients undergoing LAGB and LSG do not share the same altered alcohol metabolism as seen in gastric bypass patients. However, all bariatric surgery patients should be counseled regarding alcohol use.

摘要

背景

严重肥胖仍是工业化世界主要的公共卫生关注点,减重手术是唯一目前有效的持久治疗方法。除了胃旁路手术外,胃带术和袖状胃切除术已成为严重肥胖症的可行治疗选择。偶尔会报道术后心理调整不佳的情况。先前已经证明,术后胃旁路手术患者的血液酒精含量(BAC)水平和清醒时间增加。本研究旨在检查接受限制性减重手术的患者的酒精代谢是否也发生改变。

研究设计

招募了 9 名接受腹腔镜可调胃带术(LAGB)和 7 名接受腹腔镜袖状胃切除术(LSG)的患者。术前、术后 3 个月和 6 个月,给予 5 盎司红酒后测量 BAC 和清醒时间。此外,参与者被要求完成一份饮酒习惯问卷。

结果

16 名总参与者平均在 6 个月时达到 44.7%的超重减轻。与术前水平(0.033%,67.8 分钟)相比,峰值 BAC 或清醒时间在 3 个月(0.032%,77.1 分钟,分别,p = 0.421)或 6 个月(0.035%,81.2 分钟,分别,p = 0.198)时没有显著变化。

结论

接受 LAGB 和 LSG 的患者与胃旁路手术患者不同,没有相同的改变后的酒精代谢。然而,所有接受减重手术的患者都应该接受有关饮酒的咨询。

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