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代谢和减重手术后的酒精滥用:新发病酒精使用障碍的长期研究的系统评价,重点关注手术类型之间的差异。

Alcohol Misuse post Metabolic and Bariatric Surgery: A Systematic Review of Longer-term Studies with Focus on new Onset Alcohol use Disorder and Differences Between Surgery Types.

机构信息

Section of Endocrinology and Investigative Medicine, Imperial College, London, UK.

Central and North West London NHS Foundation Trust, London, UK.

出版信息

Curr Obes Rep. 2024 Sep;13(3):596-616. doi: 10.1007/s13679-024-00577-w. Epub 2024 Jun 8.

Abstract

BACKGROUND

Evidence suggests an increased risk of alcohol problems post-surgery where no problematic alcohol use was present prior to surgery which may be different across types of surgery.

OBJECTIVE

To characterise the risk of new onset alcohol misuse post bariatric surgery, differences between surgeries and the impact over time.

METHODS

All published studies on new and relapsing alcohol use were reviewed. Data were classed as 'subjective' (clinical interview, self-report questionnaires) and 'objective' (hospital admissions, substance misuse programmes) and further categorised by follow up time - 'shorter-term' (one year), 'medium-term' (one year to two years) and 'long-term' (> two years).

RESULTS

Twenty-three of the forty-two studies included in the review reported new onset data. Nine studies reported on differences between surgery types. In those reporting objective measures, all of which were long term, RYGB carried a higher risk than SG, followed by LAGB. All but one study using subjective measures reported a small but significant number of new onset concerning alcohol use, and comparisons between surgery types had more varied results than the objective measures. Studies of substance abuse programmes found high rates of new onset cases (17-60%).

CONCLUSION

This systematic review provides support for the consensus guidance suggesting patients should be informed of a small but significant risk of new onset alcohol use following bariatric surgery, with the strongest evidence in the medium- to long-term and in those who have had RYGB followed by SG.

摘要

背景

有证据表明,手术后出现酒精问题的风险增加,而在手术前不存在任何问题性饮酒行为,这种风险在不同类型的手术中可能有所不同。

目的

描述减重手术后新发生的酒精滥用风险,不同手术之间的差异以及随时间的影响。

方法

综述了所有关于新发生和复发性酒精使用的已发表研究。数据分为“主观”(临床访谈、自我报告问卷)和“客观”(住院记录、药物滥用项目),并根据随访时间进一步分为“短期”(一年)、“中期”(一年至两年)和“长期”(两年以上)。

结果

在纳入的 42 项研究中,有 23 项报告了新发生的数据。有 9 项研究报告了手术类型之间的差异。在报告客观测量结果的研究中,所有研究均为长期随访,RYGB 的风险高于 SG,其次是 LAGB。所有使用主观测量的研究都报告了一小部分新发生的令人担忧的酒精使用病例,且手术类型之间的比较结果与客观测量结果相比更为多样。药物滥用项目的研究发现新发病例率较高(17-60%)。

结论

本系统综述为共识指南提供了支持,表明患者应被告知在接受减重手术后,会有新发生酒精使用的小但显著的风险,在中至长期以及接受 RYGB 后接受 SG 的患者中,证据最强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c3/11306568/6ec76052c1e2/13679_2024_577_Fig1_HTML.jpg

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