Herranz González-Botas Jesús, Padín Seara Anselmo
Servicio de Otorrinolaringología, Complejo Hospitalario Universitario A Coruña, A Coruña, España.
Acta Otorrinolaringol Esp. 2012 Sep-Oct;63(5):370-5. doi: 10.1016/j.otorri.2012.05.001. Epub 2012 Jul 5.
To evaluate whether a nasal gel, administrated using a radial-hole inhaler, reaches the olfactory cleft and if a different administration method influences distribution.
Sixteen healthy volunteers underwent a nasal endoscopy at 1 and 7minutes after the administration of a intranasal gel, with a different method in each fossa.
No dye deposition was identified at the olfactory cleft, middle turbinate or middle meatus. In all cases the gel was identified at the nasal vestibule. On the right side, the second most frequent dye identification area was the inferior turbinate, with a rate of 87% at the first minute and 75% at 7 minutes. It was followed by the septum (75 and 62%) and the inferior meatus (6.2 and 12.5%). On the left side, the second most frequent stained area was the septum (18.7 and 13.5%), followed by the inferior meatus (6.5 and 65%). No inferior turbinate staining was found in the left side. There was a significant difference in the deposition rate at the septum (P<.01) and inferior turbinate (P<.001), when both administration methods were compared.
No nasal gel, administrated using a radial-hole inhaler, was found at the olfactory cleft, middle turbinate or middle meatus. Gel distribution was located at the anterior and inferior portion of the nose, independent of the administration method used. Significantly different gel distribution rates were found at the septum and inferior turbinate when the 2 administration methods were compared.
评估使用径向孔吸入器给药的鼻腔凝胶是否能到达嗅裂，以及不同的给药方法是否会影响其分布。
16名健康志愿者在鼻内凝胶给药后1分钟和7分钟接受鼻内镜检查，每个鼻腔采用不同的方法。
在嗅裂、中鼻甲或中鼻道未发现染料沉积。在所有病例中，凝胶均在鼻前庭被发现。右侧，第二常见的染料识别区域是下鼻甲，第1分钟时的发生率为87%，第7分钟时为75%。其次是鼻中隔（75%和62%）和下鼻道（6.2%和12.5%）。左侧，第二常见的染色区域是鼻中隔（18.7%和13.5%），其次是下鼻道（6.5%和65%）。左侧未发现下鼻甲染色。比较两种给药方法时，鼻中隔（P<0.01）和下鼻甲（P<0.001）的沉积率存在显著差异。
使用径向孔吸入器给药的鼻腔凝胶在嗅裂、中鼻甲或中鼻道未被发现。凝胶分布位于鼻的前部和下部，与所用的给药方法无关。比较两种给药方法时，鼻中隔和下鼻甲的凝胶分布率存在显著差异。
