嗅觉功能障碍再探讨：对化学物质所致职业性嗅觉功能障碍的重新评估
Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals.
作者信息
Werner Sabine, Nies Eberhard
机构信息
Institute for Occupational Safety and Health of the German Social Accident Insurance, Unit Toxicology of Industrial Chemicals, Alte Heerstrasse 111, 53757 Sankt Augustin, Germany.
出版信息
J Occup Med Toxicol. 2018 Sep 4;13:28. doi: 10.1186/s12995-018-0209-6. eCollection 2018.
Abstract
Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive epidemiological investigations into the olfactotoxic effect of working substances show that the human sense of smell may be impaired by exposure to metal compounds involving cadmium, chromium and nickel, and to formaldehyde. This conclusion is supported by the results of animal experiments. The level of evidence for a relationship between olfactory dysfunction and workplace exposure to other substances is relatively weak.
摘要
职业接触多种单一化学物质已被证实与嗅觉功能障碍有关，主要体现在个别病例描述中。针对工作场所化学物质嗅觉毒性作用的全面流行病学调查表明，接触镉、铬和镍等金属化合物以及甲醛可能会损害人类嗅觉。动物实验结果也支持这一结论。嗅觉功能障碍与工作场所接触其他物质之间关系的证据水平相对较弱。
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