Department of Head and Neck Surgery, Zhejiang Cancer Hospital, China.
Cancer Lett. 2013 Sep 10;338(1):47-56. doi: 10.1016/j.canlet.2012.06.013. Epub 2012 Jul 4.
Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.
头颈部鳞状细胞癌（HNSCC）是全球第 6 常见的癌症。复发，被认为涉及癌症干细胞（CSC），以及转移的发展是常见的，生存率仍然很低。上皮-间充质转化（EMT）是转移的关键事件，越来越多的证据表明 EMT 与 CSC 之间存在联系。microRNAs 调节包括 EMT 在内的多种细胞过程，并且与 CSC 表型有关。这篇综述旨在强调 EMT 涉及的关键事件，讨论它们在 HNSCC 进展和转移中的相关性，并探讨将 EMT 作为 HNSCC 新疗法的可能性。
