Togni Lucrezia, Caponio Vito Carlo Alberto, Zerman Nicoletta, Troiano Giuseppe, Zhurakivska Khrystyna, Lo Muzio Lorenzo, Balercia Andrea, Mascitti Marco, Santarelli Andrea
Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Via Tronto 10/A, 60126 Ancona, Italy.
Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.
Cancers (Basel). 2022 Jul 22;14(15):3571. doi: 10.3390/cancers14153571.
Tumor Budding (TB) represents a single cancer cell or a small cluster of less than five cancer cells on the infiltrative tumor front. Accumulating evidence suggests TB is an independent prognostic factor in oral squamous cell carcinoma (OSCC). However, its exact role is not yet elucidated, and a standardized scoring system is still necessary. The study aims to extensively review the literature data regarding the prognostic role of TB in OSCC. The results of TB are an independent prognostic factor of poor survival outcomes in OSCC. To date, the manual detection of hematoxylin and eosin-staining or pancytokeratin-immunostaining sections are the most commonly used methods. Between the several cut-offs, the two-tier system with five buds/field cut-offs provides better risk stratification. The prognostic role of the BD model in predicting survival outcomes was extensively validated; however, the inclusion of DOI, which is already a staging parameter, encouraged other authors to propose other models, integrating TB count with other adverse risk factors, such as the tumor-stroma ratio and tumor-infiltrated lymphocytes. The prognostic relevance of TB in OSCC highlights its evaluation in daily pathological practice. Therefore, the TB detection method and the TB scoring system should be validated based on tumor stage and site.
肿瘤芽生（TB）是指浸润性肿瘤前沿的单个癌细胞或少于五个癌细胞的小簇。越来越多的证据表明，TB是口腔鳞状细胞癌（OSCC）的独立预后因素。然而，其确切作用尚未阐明，仍需要一个标准化的评分系统。本研究旨在广泛回顾关于TB在OSCC中预后作用的文献数据。TB的结果是OSCC患者生存结局不良的独立预后因素。迄今为止，苏木精和伊红染色或全细胞角蛋白免疫染色切片的手动检测是最常用的方法。在几种临界值中，以五个芽/视野为临界值的两级系统提供了更好的风险分层。BD模型在预测生存结局方面的预后作用得到了广泛验证；然而，由于DOI已经是一个分期参数，其他作者鼓励提出其他模型，将TB计数与其他不良风险因素（如肿瘤-基质比和肿瘤浸润淋巴细胞）相结合。TB在OSCC中的预后相关性突出了其在日常病理实践中的评估。因此，应根据肿瘤分期和部位对TB检测方法和TB评分系统进行验证。
