Department of Surgery (Head and Neck Service), Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Contemp Clin Trials. 2012 Sep;33(5):942-8. doi: 10.1016/j.cct.2012.07.004. Epub 2012 Jul 5.
Screening and recruitment of qualified subjects for clinical trials is an essential component of translational research, and it can be quite challenging if the most efficient recruitment method is not utilized. In this report, we describe a successful web-based screening and accrual method used in a randomized prospective chemoprevention clinical trial with urinary biomarker endpoints. The targeted study population was a group of at-risk healthy current smokers with no evidence of lung disease. Craigslist was used as the sole recruitment modality for this study. All interested subjects were directed to a pre-screening website, in which subject questionnaire responses were linked to the study coordinator's secure e-mail account. Of the 429 initial inquiries, 189 individuals were initially eligible based on the questionnaire response. One hundred twenty-two people were telephone-screened, of whom 98 subjects were consented, 84 were randomized and 77 subjects completed the study successfully. Utilizing this single web-based advertising strategy, accrual for the trial was completed 7 months prior to the projected date. Craigslist is a cost effective and efficient web-based resource that can be utilized in accruing subjects to some chemoprevention trials.
筛选和招募合格的临床试验受试者是转化研究的一个重要组成部分，如果不能利用最有效的招募方法，这可能是一项极具挑战性的任务。在本报告中，我们描述了一种成功的基于网络的筛选和入组方法，该方法用于一项具有尿生物标志物终点的随机前瞻性化学预防临床试验。目标研究人群是一组有风险的、目前无肺部疾病的健康吸烟人群。 Craigslist 是这项研究唯一的招募方式。所有感兴趣的受试者都被引导到一个预筛选网站，在该网站上，受试者的问卷回答与研究协调员的安全电子邮件账户相关联。在最初的 429 次询问中，有 189 人根据问卷回答初步合格。有 122 人接受了电话筛查，其中 98 名受试者同意参与，84 名受试者被随机分组，77 名受试者成功完成了研究。利用这种单一的基于网络的广告策略，试验的入组提前 7 个月完成了预计的日期。 Craigslist 是一种具有成本效益和高效的基于网络的资源，可以用于某些化学预防试验的受试者招募。
