Raj Aditi, Gaikwad Vaishali, Amarapurkar Anjali
Department of Pathology, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai, Maharashtra, India.
Int J Health Sci (Qassim). 2021 May-Jun;15(3):41-43.
Histiocytic sarcoma (HS) is an exceedingly rare lymphohematopoietic malignancy with morphological and immunophenotypic characteristics of mature tissue histiocytes. We report a unique case of a HS with synchronous skin and gastrointestinal tract involvement which has not been reported in literature till date to the best of our knowledge. A 70-year-old male farmer presented with multiple ulcerated skin lesions ranging from 0.5 to 10 cm all over the body. Autopsy revealed multiple transmural nodular deposits in stomach, intestines, head of pancreas, and peripancreatic tissue. Histopathology and immunohistochemistry profile was consistent with HS exhibiting positivity for CD68, CD163, and lysozyme. CD 163 identifies histiocytic malignancies with high degree of specificity and has become a promising marker for their diagnosis.
组织细胞肉瘤（HS）是一种极其罕见的淋巴造血系统恶性肿瘤，具有成熟组织细胞的形态学和免疫表型特征。据我们所知，我们报告了一例独特的同时累及皮肤和胃肠道的组织细胞肉瘤病例，此前文献中尚未有过报道。一名70岁男性农民全身出现多处大小从0.5厘米至10厘米不等的溃疡性皮肤病变。尸检发现胃、肠道、胰头和胰腺周围组织有多个透壁结节状沉积物。组织病理学和免疫组织化学特征与组织细胞肉瘤一致，CD68、CD163和溶菌酶呈阳性。CD163对组织细胞恶性肿瘤具有高度特异性识别能力，已成为其诊断的一个有前景的标志物。
