Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.
Osteoarthritis Cartilage. 2012 Oct;20(10):1161-9. doi: 10.1016/j.joca.2012.06.008. Epub 2012 Jul 5.
Upward migration of the subchondral bone plate is associated with osteochondral repair. The aim of this study was to quantitatively monitor the sequence of subchondral bone plate advancement in a lapine model of spontaneous osteochondral repair over a 1-year period and to correlate these findings with articular cartilage repair.
Standardized cylindrical osteochondral defects were created in the rabbit trochlear groove. Subchondral bone reconstitution patterns were identified at five time points. Migration of the subchondral bone plate and areas occupied by osseous repair tissue were determined by histomorphometrical analysis. Tidemark formation and overall cartilage repair were correlated with the histomorphometrical parameters of the subchondral bone.
The subchondral bone reconstitution pattern was cylindrical at 3 weeks, infundibuliform at 6 weeks, plane at 4 and 6 months, and hypertrophic after 1 year. At this late time point, the osteochondral junction advanced 0.19 [95% confidence intervals (CI) 0.10-0.30] mm above its original level. Overall articular cartilage repair was significantly improved by 4 and 6 months but degraded after 1 year. Subchondral bone plate migration correlated with tidemark formation (r = 0.47; P < 0.0001), but not with the overall score of the repair cartilage (r = 0.11; P > 0.44).
The subchondral bone plate is reconstituted in a distinct chronological order. The lack of correlation suggests that articular cartilage repair and subchondral bone reconstitution proceed at a different pace and that the advancement of the subchondral bone plate is not responsible for the diminished articular cartilage repair in this model.
软骨下骨板的向上迁移与骨软骨修复有关。本研究的目的是在兔自发性骨软骨修复模型中，定量监测软骨下骨板在 1 年内的进展顺序，并将这些发现与关节软骨修复相关联。
在兔滑车沟中创建标准化的圆柱形骨软骨缺损。在五个时间点确定软骨下骨重建模式。通过组织形态计量学分析确定软骨下骨板的迁移和骨修复组织的占据区域。通过组织形态计量学参数来确定潮线形成和整体软骨修复与软骨下骨的相关性。
软骨下骨重建模式在 3 周时为圆柱形，在 6 周时为漏斗形，在 4 个月和 6 个月时为平面形，在 1 年后为肥大性。在这个晚期时间点，骨软骨交界处向上迁移了 0.19 [95%置信区间（CI）0.10-0.30]毫米。整体关节软骨修复在 4 个月和 6 个月时显著改善，但在 1 年后退化。软骨下骨板迁移与潮线形成相关（r=0.47；P<0.0001），但与修复软骨的整体评分无关（r=0.11；P>0.44）。
软骨下骨板以特定的时间顺序重建。缺乏相关性表明关节软骨修复和软骨下骨重建以不同的速度进行，软骨下骨板的推进并不是导致该模型中关节软骨修复减少的原因。
