Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam 632 509, Vellore District, Tamil Nadu, India.
Exp Parasitol. 2012 Oct;132(2):180-4. doi: 10.1016/j.exppara.2012.06.012. Epub 2012 Jul 4.
Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The aim of this study was to evaluate the in vitro antileishmanial activity of the acetone and methanol leaf extracts of Anisomeles malabarica, flower of Gloriosa superba, leaf of Ocimum basilicum, leaf and seed of Ricinus communis against promastigotes form of Leishmania donovani. Antiparasitic evaluations of different plant crude extracts were performed on 96 well plates at 37°C for 24-48 h. Out of the 10 experimental plant extracts tested, the leaf methanol extracts of A. malabarica, and R. communis showed good antileishmanial activity (IC(50)=126±19.70 and 184±39.33 μg/mL), respectively against promastigotes. Effective antileishmanial activity was observed making these plants as good candidates for isolation of antiprotozoal compounds which could serve as new lead structures for drug development.
利什曼原虫属原生动物引起的感染是一个全球性的主要健康问题，在发展中国家高度流行。本研究旨在评估 Anisomeles malabarica 的丙酮和甲醇叶提取物、Gloriosa superba 的花、Ocimum basilicum 的叶、Ricinus communis 的叶和种子对利什曼原虫无鞭毛体形式的抗利什曼原虫活性。在 96 孔板中，在 37°C 下对不同植物粗提取物进行了 24-48 小时的抗寄生虫评估。在测试的 10 种实验植物提取物中，A. malabarica 的甲醇叶提取物和 R. communis 的甲醇叶提取物对无鞭毛体表现出良好的抗利什曼原虫活性（IC50=126±19.70 和 184±39.33 μg/mL）。观察到有效的抗利什曼原虫活性，使这些植物成为分离抗原生动物化合物的良好候选物，这些化合物可作为药物开发的新先导结构。
