Wispelwey B, Tunkel A R, Scheld W M
Division of Infectious Diseases, University of Virginia School of Medicine, Charlottesville.
Infect Dis Clin North Am. 1990 Dec;4(4):645-59.
Bacterial meningitis continues to be an important cause of morbidity and mortality despite the availability of effective bactericidal antibiotics. Penicillin or ampicillin remains the drug of choice for meningitis caused by Streptococcus pneumoniae and Neisseria meningitidis. The third generation cephalosporins have revolutionized the treatment of gram-negative meningitis. Future therapy for bacterial meningitis will use recent developments in the understanding of pathogenic and pathophysiologic mechanisms underlying this disease.
尽管有有效的杀菌抗生素，但细菌性脑膜炎仍然是发病和死亡的重要原因。青霉素或氨苄西林仍然是由肺炎链球菌和脑膜炎奈瑟菌引起的脑膜炎的首选药物。第三代头孢菌素彻底改变了革兰氏阴性菌脑膜炎的治疗方法。细菌性脑膜炎的未来治疗将利用对该疾病潜在的致病和病理生理机制的最新认识。
