Lin H, Iannettoni M D, Goldblum J R, Bolling S F
Section of Thoracic Surgery, University of Michigan Hospitals, Ann Arbor 48109.
J Heart Transplant. 1990 Nov-Dec;9(6):720-3.
Current experimental models of heart transplantation include a period of ischemia after donor harvest, resulting in rhythm disturbances, myocardial distention, and reperfusion injury on implantation. A model of cervical heterotopic heart transplantation that avoids ischemia by using retrograde perfusion was developed. More than 100 consecutive successful transplantations have been performed both as control protocols and as a part of experimental protocols. The advantages of this technique include: avoidance of ischemia and reperfusion injury, prevention of myocardial damage caused by overdistention, and potential evaluation of pretreatment regimens for transplanted hearts.
目前的心脏移植实验模型包括供体心脏获取后的一段缺血期，这会导致心律失常、心肌扩张以及植入时的再灌注损伤。一种通过逆行灌注避免缺血的颈部异位心脏移植模型已被开发出来。作为对照方案以及实验方案的一部分，已经连续成功进行了100多次移植手术。该技术的优点包括：避免缺血和再灌注损伤、预防过度扩张引起的心肌损伤以及对移植心脏预处理方案的潜在评估。
