缺磷促进铜绿假单胞菌的群集运动和细胞毒性。
Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa.
机构信息
Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Appl Environ Microbiol. 2012 Sep;78(18):6762-8. doi: 10.1128/AEM.01015-12. Epub 2012 Jul 6.
Abstract
We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.
摘要
我们研究了铜绿假单胞菌在缺磷（0.2mM）条件下与磷充足（1mM）条件下的转录反应。这引发了与磷酸盐摄取、群体感应、趋化性、毒素分泌和调节相关的基因的巨大转录变化。这种失调还导致了增加的毒力相关表型，包括群集运动和细胞毒性。
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