Liggins Institute, University of Auckland, Auckland, New Zealand.
Diabetes Care. 2012 Oct;35(10):2089-94. doi: 10.2337/dc11-2331. Epub 2012 Jul 6.
To determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration.
The study evaluated 53 adolescents with type 1 diabetes and 22 control adolescents. Baseline data included peak exercise capacity and body composition by dual-energy X-ray absorptiometry. Left ventricular functional parameters were obtained at rest and during acute exercise using magnetic resonance imaging.
Compared with nondiabetic control subjects, adolescents with type 1 diabetes had lower exercise capacity (44.7 ± 09 vs. 48.5 ± 1.4 mL/kg fat-free mass [FFM]/min; P < 0.05). Stroke volume was reduced in the diabetes group at rest (1.86 ± 0.04 vs. 2.05 ± 0.07 mL/kg FFM; P = 0.02) and during acute exercise (1.89 ± 0.04 vs. 2.17 ± 0.06 mL/kg FFM; P = 0.01). Diabetic adolescents also had reduced end-diastolic volume at rest (2.94 ± 0.06 vs. 3.26 ± 0.09 mL/kg FFM; P = 0.01) and during acute exercise (2.78 ± 0.05 vs. 3.09 ± 0.08 mL/kg FFM; P = 0.01). End-systolic volume was lower in the diabetic group at rest (1.08 ± 0.03 vs. 1.21 ± 0.04 mL/kg FFM; P = 0.01) but not during acute exercise. Exercise capacity and resting and exercise stroke volumes were correlated with glycemic control but not with diabetes duration.
Adolescents with type 1 diabetes have reduced exercise capacity and display alterations in cardiac function compared with nondiabetic control subjects, associated with reduced stroke volume during exercise.
确定 1 型糖尿病青少年在静息和急性运动期间是否存在左心室功能变化，以及这些变化是否受代谢控制和糖尿病病程的影响。
该研究评估了 53 名 1 型糖尿病青少年和 22 名对照青少年。基线数据包括双能 X 射线吸收法测量的峰值运动能力和身体成分。使用磁共振成像在静息和急性运动期间获得左心室功能参数。
与非糖尿病对照组相比，1 型糖尿病青少年的运动能力较低（44.7 ± 09 比 48.5 ± 1.4 mL/kg 去脂体重/分钟；P < 0.05）。糖尿病组在静息时（1.86 ± 0.04 比 2.05 ± 0.07 mL/kg 去脂体重；P = 0.02）和急性运动时（1.89 ± 0.04 比 2.17 ± 0.06 mL/kg 去脂体重；P = 0.01）的每搏量降低。糖尿病青少年在静息时（2.94 ± 0.06 比 3.26 ± 0.09 mL/kg 去脂体重；P = 0.01）和急性运动时（2.78 ± 0.05 比 3.09 ± 0.08 mL/kg 去脂体重；P = 0.01）的舒张末期容积也较低。在静息时（1.08 ± 0.03 比 1.21 ± 0.04 mL/kg 去脂体重；P = 0.01），而不是在急性运动期间，糖尿病组的收缩末期容积较低。运动能力和静息及运动时的每搏量与血糖控制相关，但与糖尿病病程无关。
与非糖尿病对照组相比，1 型糖尿病青少年的运动能力降低，且与运动时的每搏量降低相关，心脏功能也存在改变。
