Department of Cardiothoracic Surgery, University Hospital, Ioannina School of Medicine, Ioannina, Greece.
Eur Rev Med Pharmacol Sci. 2012 May;16(5):691-4.
Extramedullary haematopoiesis is a very rare cause of a posterior mediastinal tumour and may be clinically confused with many other mediastinal tumours; benign or malignant. Extramedullary haematopoiesis is a really rare cause of haemothorax and usually it is diagnosed incidentally. Extramedullary masses complicating thalassemias, apart from the known complications, may also bleed and produce acute manifestations like dyspnoea and fatigue. Pathologically, the masses are soft, deep red, and resemble spleen tissue on the cut surface. Histologically, they are formed of hematopoietic tissue mixed with adipose elements. The mass is extremely vascular and contains some fibrous tissue. This particular structure renders the mass prone to haemorrhage. We report a case of posterior mediastinal extramedullary haematopoietic mass in a 56-year-old man who presented with non-specific symptomatology and a paravertebral mass on chest X-ray and in the chest computed tomography. A percutaneous biopsy approach could be technically difficult due to the special location of the mass. Video assisted thoracic surgery (VATS), is a minimal invasive and alternative way of diagnosis, biopsy and treatment of these cases. Diagnosis was achieved in our patient by mini thoracotomy and open biopsy in order to prevent bleeding or neurological damage.
髓外化生是一种非常罕见的后纵隔肿瘤的病因,可能与许多其他纵隔肿瘤混淆;良性或恶性。髓外化生是血胸的一个非常罕见的病因,通常是偶然诊断出来的。除了已知的并发症外,地中海贫血症并发髓外肿块也可能会出血并产生呼吸困难和疲劳等急性表现。从病理上看,肿块质地柔软,呈深红色,切面类似脾脏组织。从组织学上看,它们由造血组织和脂肪组织混合而成。肿块极其血管化,含有一些纤维组织。这种特殊的结构使肿块容易出血。我们报告了一例 56 岁男性的后纵隔髓外造血肿块病例,该患者表现为非特异性症状和 X 线胸片和胸部 CT 上的椎旁肿块。由于肿块的特殊位置,经皮活检方法可能具有技术难度。电视辅助胸腔镜手术(VATS)是一种微创的替代方法,可用于这些病例的诊断、活检和治疗。为了防止出血或神经损伤,我们的患者通过小开胸术和开放性活检来确诊。