儿童时期的智商与中年时期非法药物使用的风险：1958 年全国儿童发展调查。
Intelligence quotient in childhood and the risk of illegal drug use in middle-age: the 1958 National Child Development Survey.
机构信息
Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement, Cardiff University, Heath Park, Cardiff, UK.
出版信息
Ann Epidemiol. 2012 Sep;22(9):654-7. doi: 10.1016/j.annepidem.2012.06.001. Epub 2012 Jul 7.
PURPOSE
High childhood IQ test scores have been associated with increased alcohol dependency and use in adult life, but the relationship between childhood IQ and illegal drug use in later life is unclear.
METHODS
Participants were 6713 members of the 1958 National Child Development Survey whose IQ was assessed at 11 years and had their lifetime illegal drug use measured at 42 years of age.
RESULTS
In analyses adjusted for a range of covariates, a 1 SD (15-point) increase in IQ scores was associated with an increased risk of illegal drug use in women: ever using cannabis (odds ratio [OR], 1.30; 95% confidence interval [95% CI], 1.16-1.45), cocaine (OR, 1.66; 95% CI, 1.21-2.27), amphetamines (OR, 1.50; 95% CI, 1.22-1.83), amyl nitrate (OR, 1.79; 95% CI, 1.30-2.46) and "magic mushrooms" (OR, 1.52; 95% CI, 1.18-1.98). Associations were of lower magnitude in men.
CONCLUSIONS
In this cohort, high childhood IQ was related to illegal drug use in adulthood.
目的
儿童期智商测试分数较高与成年后酗酒和吸毒依赖的风险增加有关，但儿童期智商与晚年非法药物使用之间的关系尚不清楚。
方法
参与者为 1958 年全国儿童发展调查的 6713 名成员，他们的智商在 11 岁时进行评估，终身非法药物使用情况在 42 岁时进行测量。
结果
在调整了一系列协变量的分析中，智商得分每增加 1 个标准差（15 分），女性非法药物使用的风险就会增加：曾使用大麻（优势比 [OR]，1.30；95%置信区间 [95%CI]，1.16-1.45）、可卡因（OR，1.66；95%CI，1.21-2.27）、安非他命（OR，1.50；95%CI，1.22-1.83）、亚硝酸戊酯（OR，1.79；95%CI，1.30-2.46）和“迷幻蘑菇”（OR，1.52；95%CI，1.18-1.98）。男性的关联程度较低。
结论
在本队列中，高儿童期智商与成年后的非法药物使用有关。
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