Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Neurobiol Learn Mem. 2012 Sep;98(2):112-21. doi: 10.1016/j.nlm.2012.07.001. Epub 2012 Jul 6.
It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α(7)-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia.
众所周知，系统预训练给予毒蕈碱拮抗剂东莨菪碱（SCP）（0.5mg/kg，ip）会导致在保留测试中出现顺行性记忆损伤。在记忆再激活后立即在海马体背侧给予α（7）烟碱受体激动剂胆碱（Ch）（0.8μg/hippocampus），可以从 SCP 诱导的记忆损伤中恢复。Ch 的这种作用具有时间依赖性，并且在未进行记忆再激活的药物处理的小鼠中，药物处理不会影响保留性能，这表明作用效果不是由于药物的非特异性影响。Ch 的作用还取决于再激活记忆的年龄。总之，我们的结果表明 Ch 通过调节记忆再巩固来发挥作用，并且 SCP 的低剂量引起的记忆损伤是记忆表达失败而不是存储缺陷。因此，除其他功能外，再巩固可能有助于在以后的测试中改变记忆表达。总之，我们的结果揭示了记忆再巩固的行为意义和生理功能的新途径，为从某些类型的健忘症中恢复记忆提供了新的策略。
