韩国有 2 型糖尿病家族史儿童的血清脂联素水平较低。
Low serum adiponectin levels in Korean children with a family history of type 2 diabetes mellitus.
机构信息
Department of Pediatrics, Sahm Yook Medical Center, Seoul, Korea.
出版信息
Horm Res Paediatr. 2012;77(6):382-7. doi: 10.1159/000339154.
BACKGROUND/AIMS: The current worldwide increases of type 2 diabetes mellitus (T2DM) in children coincide with increases in the prevalence of obesity. We investigated the insulin resistance and adiponectin levels of children and adolescents with a family history of T2DM (FHD).
METHODS
Our sample included 131 children and adolescents aged 8-15 years. Fasting plasma glucose, lipids, fasting insulin, adiponectin levels and HOMA-IR were analyzed according to FHD and obesity. Oral glucose tolerance tests were performed in all subjects except non-obese subjects without FHD.
RESULTS
Adiponectin levels of subjects with FHD were significantly lower than those of subjects without FHD in both the obese and nonobese groups. HOMA-IR was significantly higher in obese subjects with FHD than in those without FHD. Adiponectin levels were found to be independently associated with FHD and Matsuda index. The frequency of impaired glucose tolerance in obese subjects with FHD was more than four times higher compared to obese subjects without FHD.
CONCLUSION
Our results suggest that FHD could be a risk factor of T2DM in obese Korean children, especially with low serum levels of adiponectin.
背景/目的：目前全球儿童 2 型糖尿病（T2DM）的发病率与肥胖症的发病率同时上升。我们研究了有 2 型糖尿病家族史（FHD）的儿童和青少年的胰岛素抵抗和脂联素水平。
方法
我们的样本包括 131 名 8-15 岁的儿童和青少年。根据 FHD 和肥胖情况分析空腹血糖、血脂、空腹胰岛素、脂联素水平和 HOMA-IR。除了无 FHD 的非肥胖者外，所有受试者均进行口服葡萄糖耐量试验。
结果
在肥胖和非肥胖组中，有 FHD 的受试者的脂联素水平明显低于无 FHD 的受试者。在有 FHD 的肥胖受试者中，HOMA-IR 明显高于无 FHD 的肥胖受试者。脂联素水平与 FHD 和 Matsuda 指数独立相关。有 FHD 的肥胖受试者的糖耐量受损频率是无 FHD 的肥胖受试者的四倍以上。
结论
我们的结果表明，FHD 可能是韩国肥胖儿童 2 型糖尿病的一个危险因素，尤其是血清脂联素水平较低的儿童。
Zotero 插件