Merzah Maryam Hamid, Diajil Ameena Ryhan
Department of Oral Diagnosis, Oral Medicine, College of Dentistry, University of Baghdad, Baghdad, Iraq.
J Med Life. 2023 Oct;16(10):1561-1565. doi: 10.25122/jml-2023-0023.
Diabetes mellitus (DM) is a chronic, metabolic condition marked by defects in insulin production, action, or both. Environmental and genetic factors can contribute to the onset of diabetes mellitus. Adiponectin, a hormone affecting pancreatic beta cell proliferation, has emerged as a potential indicator of diabetes risk. This cross-sectional study aimed to evaluate serum and salivary adiponectin levels as predictors of diabetes mellitus in children with/without a family history of diabetes mellitus. The study was conducted at Al-Zahra Hospital in Najaf city and included 125 children aged 5 to 16. Data on demographics, including name, age, and gender, were collected, and body mass index (BMI) was assessed. Serum and salivary adiponectin levels were measured and analyzed in relation to family history and BMI. Children with a family history of DM had high serum adiponectin (ADP) levels. Serum adiponectin levels were significantly higher in children with first-degree relatives having a history of diabetes mellitus, except for cases involving mothers and other relatives with diabetes mellitus history (p<0.05). Furthermore, serum adiponectin levels were higher in obese children. Salivary adiponectin levels were significantly elevated in children with a maternal family history of diabetes (p=0.01), while no significant correlation was found with BMI. A significant negative correlation (r=-0.180, p=0.05) between salivary and serum adiponectin concentrations was observed. Compared to children with a normal, healthy weight, children with obesity had decreased salivary adiponectin levels and increased serum adiponectin levels.
糖尿病（DM）是一种慢性代谢性疾病，其特征是胰岛素分泌、作用或两者均存在缺陷。环境和遗传因素可导致糖尿病的发病。脂联素是一种影响胰腺β细胞增殖的激素，已成为糖尿病风险的潜在指标。这项横断面研究旨在评估血清和唾液脂联素水平，作为有/无糖尿病家族史儿童患糖尿病的预测指标。该研究在纳杰夫市的宰赫拉医院进行，纳入了125名5至16岁的儿童。收集了包括姓名、年龄和性别的人口统计学数据，并评估了体重指数（BMI）。测量并分析了血清和唾液脂联素水平与家族史和BMI的关系。有糖尿病家族史的儿童血清脂联素（ADP）水平较高。有糖尿病家族史的一级亲属的儿童血清脂联素水平显著更高，但涉及有糖尿病病史的母亲和其他亲属的情况除外（p<0.05）。此外，肥胖儿童的血清脂联素水平更高。有糖尿病母系家族史的儿童唾液脂联素水平显著升高（p=0.01），而与BMI无显著相关性。观察到唾液和血清脂联素浓度之间存在显著负相关（r=-0.180，p=0.05）。与体重正常、健康的儿童相比，肥胖儿童的唾液脂联素水平降低，血清脂联素水平升高。
