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Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment.暴露于儿童期虐待的女性中 Adcyap1r1 基因型、创伤后应激障碍和抑郁。
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Psychiatry: A molecular shield from trauma.精神病学：抵御创伤的分子屏障。
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Regulation of behavioral responses to single prolonged stress in male and female rats: Role of PACAP.雄性和雌性大鼠对单次长时间应激的行为反应调节：垂体腺苷酸环化酶激活肽的作用。
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HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment.在童年期受虐待程度较低而非较高的女性中，艾滋病毒感染状况会影响创伤后应激障碍（PTSD）症状的严重程度、心理生理学及心率变异性。
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Genome-wide association study identified six loci associated with adverse drug reactions to aripiprazole in schizophrenia patients.全基因组关联研究确定了六个与精神分裂症患者对阿立哌唑药物不良反应相关的基因座。
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Does age matter in genetics? The role of ADCYAP1R1 in sex-specific risk for posttraumatic stress disorder in trauma-exposed preadolescent children.年龄在遗传学中重要吗？ADCYAP1R1 在创伤暴露前青春期儿童创伤后应激障碍的性别特异性风险中的作用。
J Psychiatr Res. 2023 Aug;164:291-295. doi: 10.1016/j.jpsychires.2023.06.024. Epub 2023 Jun 19.
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The functional heterogeneity of PACAP: Stress, learning, and pathology.PACAP 的功能异质性：应激、学习和病理学。
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Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder.循环 PACAP 水平与创伤后应激障碍患者杏仁核默认模式网络静息状态连接增加有关。
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Effect of transcutaneous cervical vagus nerve stimulation on the pituitary adenylate cyclase-activating polypeptide (PACAP) response to stress: A randomized, sham controlled, double blind pilot study.经皮颈迷走神经刺激对垂体腺苷酸环化酶激活多肽（PACAP）应激反应的影响：一项随机、假刺激对照、双盲试点研究。
Compr Psychoneuroendocrinol. 2020 Oct 27;4:100012. doi: 10.1016/j.cpnec.2020.100012. eCollection 2020 Nov.
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Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits.创伤后应激障碍：从细胞到回路的临床和转化神经科学。
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Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory.学习与记忆中的垂体腺苷酸环化酶激活多肽
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Prefrontal cortex PACAP signaling: organization and role in stress regulation.前额皮质 PACAP 信号：在应激调节中的组织和作用。
Stress. 2021 Mar;24(2):196-205. doi: 10.1080/10253890.2021.1887849. Epub 2021 Mar 17.

本文引用的文献

1
Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder.创伤后平民样本中增强的惊跳反应和心率变异性：创伤后应激障碍的潜在性别特异性相关因素。
Psychosom Med. 2012 Feb-Mar;74(2):153-9. doi: 10.1097/PSY.0b013e318240803a. Epub 2012 Jan 27.
2
Physiological markers of anxiety are increased in children of abused mothers.被虐待母亲的孩子的焦虑生理标志物增加。
J Child Psychol Psychiatry. 2011 Aug;52(8):844-52. doi: 10.1111/j.1469-7610.2011.02410.x. Epub 2011 Apr 19.
3
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.创伤后应激障碍与 PACAP 和 PAC1 受体有关。
Nature. 2011 Feb 24;470(7335):492-7. doi: 10.1038/nature09856.
4
Roles for pituitary adenylate cyclase-activating peptide (PACAP) expression and signaling in the bed nucleus of the stria terminalis (BNST) in mediating the behavioral consequences of chronic stress.在介导慢性应激的行为后果中，垂体腺苷酸环化酶激活肽（PACAP）表达和信号在终纹床核（BNST）中的作用。
J Mol Neurosci. 2010 Nov;42(3):327-40. doi: 10.1007/s12031-010-9364-7. Epub 2010 Apr 20.
5
An inventory for measuring depression.一份用于测量抑郁的量表。
Arch Gen Psychiatry. 1961 Jun;4:561-71. doi: 10.1001/archpsyc.1961.01710120031004.
6
Development and validation of a brief screening version of the Childhood Trauma Questionnaire.儿童创伤问卷简短筛查版的编制与验证
Child Abuse Negl. 2003 Feb;27(2):169-90. doi: 10.1016/s0145-2134(02)00541-0.
7
Effect of darkness on acoustic startle in Vietnam veterans with PTSD.黑暗对患有创伤后应激障碍的越南退伍军人听觉惊吓反应的影响。
Am J Psychiatry. 1998 Jun;155(6):812-7. doi: 10.1176/ajp.155.6.812.
8
Startle modulation in children at risk for anxiety disorders and/or alcoholism.焦虑症和/或酒精中毒风险儿童的惊吓调节
J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):925-32. doi: 10.1097/00004583-199707000-00014.

PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children.

作者信息

Jovanovic T, Norrholm S D, Davis J, Mercer K B, Almli L, Nelson A, Cross D, Smith A, Ressler K J, Bradley B

出版信息

Mol Psychiatry. 2013 Jul;18(7):742-3. doi: 10.1038/mp.2012.98. Epub 2012 Jul 10.

DOI:10.1038/mp.2012.98
PMID:22776899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3750970/
Abstract
摘要