Centre for Infectious Disease Control, National Institute for Public Health and the Environment, A. van Leeuwenhoeklaan 9, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.
Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):3207-9. doi: 10.1007/s10096-012-1686-7. Epub 2012 Jul 10.
The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (≥1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes.
高的 I 期 IgG 抗体滴度的存在可能表明慢性感染，并可能通过输血传播科氏立克次体。在荷兰 Q 热爆发期间，对 1 年后急性 Q 热的一大组个体进行了酶联免疫吸附试验（EIA）与参考免疫荧光分析（IFA）的比较。EIA 在检测高（≥1：1024）I 期 IgG 抗体滴度时的敏感性为 100%。用 EIA 进行筛查并对所有 EIA 阳性结果用 IFA 进行确认的成本远低于用 IFA 筛查所有供体。在筛查方案的成本效益分析中应考虑到这一点。
