Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Chiayi and Chang Gung University College of Medicine, Chiayi, Taiwan.
Laryngoscope. 2012 Sep;122(9):1988-93. doi: 10.1002/lary.23432. Epub 2012 Jul 9.
OBJECTIVES/HYPOTHESIS: This study investigated the association between the results of nasopharyngeal (NPX) biopsies and clinical manifestations in patients with suspected nasopharyngeal carcinoma (NPC).
Retrospective cohort study.
Four hundred seventy-three patients with 512 NPX biopsies were enrolled. The statistical analyses were conducted to evaluate clinical significance and screening performance for suspected NPC.
The negative rate of all NPX biopsies was 69.7% (345/495), and the majority of the noncancerous group revealed lymphoid hyperplasias (208/345, 60.3%). The three diagnostic capabilities of NPX mass, epistaxis (EPI), neck mass (NM), EPI-NM, EPI-NPX mass, NM-NPX mass, and EPI-NM-NPX mass were 0.595, 0.557, 0.735, 0.609, 0.566, 0.748, and 0.600, respectively.
Although NPX mass, EPI, and NM were significant to identify suspected NPC, the diagnostic capabilities of combining EPI, NM, and NPX were still low. A large number of noncancerous biopsy results were obtained due to lymphoid hyperplasias often being mistaken as NPC.
目的/假设：本研究旨在探讨疑似鼻咽癌（NPC）患者的鼻咽部（NPX）活检结果与临床表现之间的关系。
回顾性队列研究。
共纳入 473 例患者的 512 次 NPX 活检。进行统计分析以评估疑似 NPC 的临床意义和筛查性能。
所有 NPX 活检的阴性率为 69.7%（345/495），非癌组中大多数为淋巴组织增生（208/345，60.3%）。NPX 肿块、鼻出血（EPI）、颈部肿块（NM）、EPI-NM、EPI-NPX 肿块、NM-NPX 肿块和 EPI-NM-NPX 肿块的三种诊断能力分别为 0.595、0.557、0.735、0.609、0.566、0.748 和 0.600。
尽管 NPX 肿块、EPI 和 NM 对识别疑似 NPC 具有重要意义，但联合 EPI、NM 和 NPX 的诊断能力仍然较低。由于淋巴组织增生常被误诊为 NPC，因此获得了大量的非癌性活检结果。
