协同辅助双功能有机催化：脂肪族和芳香族亚胺的对映选择性曼尼希反应。
Cooperative assistance in bifunctional organocatalysis: enantioselective Mannich reactions with aliphatic and aromatic imines.
机构信息
Department of Chemistry, Nanoscience Center, University of Jyväskylä, POB 35, 40014 JYU, Finland.
出版信息
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8495-9. doi: 10.1002/anie.201203852. Epub 2012 Jul 9.
PMID:22777736
Abstract
Hold them tight: Guided by X-ray structures, bifunctional thiourea catalysts containing an activating intramolecular hydrogen bond were redesigned. The new catalysts were used to effect a highly enantioselective Mannich reaction between malonates and both aliphatic and aromatic imines (see scheme; Boc=tert-butoxycarbonyl).
摘要
紧紧握住它们
受 X 射线结构的指导，重新设计了含有激活分子内氢键的双功能硫脲催化剂。新的催化剂被用于在丙二酸酯和脂肪族及芳香族亚胺之间进行高度对映选择性的曼尼希反应（见方案；Boc=叔丁氧羰基）。
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