Knorr A, Herrmann T, Voigtmann L
Strahlenbiologisches Labor der Strahlentherapieabteilung, Medizinische Akademie, Carl Gustav Carus, Dresden.
Radiobiol Radiother (Berl). 1990;31(5):449-58.
To test the radiogenic reaction of normal lung tissue experiments were done in 99 young pigs altogether. The radiation field included the total right lobe of the lung, 5 fractions of photons or neutrons (mean energy 6.2 MeV) were applied in a total treatment of 5 or 35 days. After killing the animals and taking the lungs the examination of tissue samples and others has been done for contents of hydroxyproline (HP) that has been used to register radiogenic injuries where the relation of irradiated and non-irradiated half of the same animal was estimated as measuring value. Above a limit of 1.13 for the HP-quotient (estimated in non-irradiated controls) there was a significant correlation with dose. Between the results of HP-quotients and histopathological findings a very good correlation was found. Calculation of RBE was done from relation of the dose values of photons and neutrons on base of the same level of injuries. In the tested total dose limit (photons: 14.25-38 Gy, neutrons 3.0-8.5 Gy) RBE-values of 3.8-4.5 were reached that correlates well with other tested criteria of the study in young pigs.
为了测试正常肺组织的放射反应，总共对99只幼猪进行了实验。辐射野包括右肺全叶，以5天或35天为一个总疗程，分5次给予光子或中子照射（平均能量6.2兆电子伏）。处死动物并取出肺脏后，对组织样本等进行检查，检测羟脯氨酸（HP）含量，该指标用于记录放射性损伤，以同一动物照射侧和未照射侧的比值作为测量值。当HP商数（在未照射对照组中估算）超过1.13的限值时，与剂量存在显著相关性。HP商数结果与组织病理学发现之间存在非常好的相关性。根据相同损伤水平下光子和中子剂量值的关系计算相对生物效应（RBE）。在所测试的总剂量范围内（光子：14.25 - 38戈瑞，中子：3.0 - 8.5戈瑞），RBE值达到3.8 - 4.5，这与幼猪研究中的其他测试标准相关性良好。
