前列腺素在神经炎症和神经退行性疾病中的作用。
Role of prostaglandins in neuroinflammatory and neurodegenerative diseases.
机构信息
Department of Pharmacology, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil.
出版信息
Mediators Inflamm. 2012;2012:946813. doi: 10.1155/2012/946813. Epub 2012 Jun 18.
Abstract
Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.
摘要
越来越多的数据表明，炎症参与了神经退行性疾病的病理生理学过程。在涉及的不同炎症介质中，前列腺素发挥着重要作用。前列腺素诱导的作用可能是通过其已知受体的激活或非经典机制介导的。在本文中，我们讨论了将前列腺素及其产生酶与某些神经疾病联系起来的证据。
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