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氟哌啶醇的减少量可在人类红细胞中进行测定。

Haloperidol reduction can be assayed in human red blood cells.

作者信息

Inaba T, Kalow W, Someya T, Takahashi S, Cheung S W, Tang S W

机构信息

Department of Pharmacology, Faculty of Medicine, University of Toronto, Ont., Canada.

出版信息

Can J Physiol Pharmacol. 1989 Nov;67(11):1468-9. doi: 10.1139/y89-237.

DOI:10.1139/y89-237
PMID:2697459
Abstract

One metabolite of haloperidol present in plasma is "reduced haloperidol." This study demonstrates that human red blood cells are capable of converting haloperidol to reduced haloperidol in vitro. The reductase involved requires NADPH, as does haloperidol (ketone) reductase in human liver cytosol.

摘要

血浆中存在的氟哌啶醇的一种代谢物是“还原氟哌啶醇”。本研究表明，人红细胞在体外能够将氟哌啶醇转化为还原氟哌啶醇。所涉及的还原酶需要NADPH，人肝细胞溶质中的氟哌啶醇（酮）还原酶也是如此。

相似文献

1
Haloperidol reduction can be assayed in human red blood cells.氟哌啶醇的减少量可在人类红细胞中进行测定。
Can J Physiol Pharmacol. 1989 Nov;67(11):1468-9. doi: 10.1139/y89-237.
2
Relation of plasma and red blood cells reduced haloperidol concentrations to haloperidol reductase activity assayed in red blood cells in psychiatric population.
Prog Neuropsychopharmacol Biol Psychiatry. 1993 Mar;17(2):257-67. doi: 10.1016/0278-5846(93)90046-u.
3
Measurement of haloperidol reductase activity in red blood cells and reduced haloperidol/haloperidol ratios in plasma in oriental psychiatric patients.东方精神病患者红细胞中氟哌啶醇还原酶活性及血浆中还原型氟哌啶醇/氟哌啶醇比率的测定。
Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(6):941-7. doi: 10.1016/0278-5846(90)90079-v.
4
Haloperidol metabolism in psychiatric patients: importance of glucuronidation and carbonyl reduction.精神科患者中氟哌啶醇的代谢：葡萄糖醛酸化和羰基还原的重要性。
J Clin Psychopharmacol. 1992 Jun;12(3):169-74.
5
Determination of haloperidol and reduced haloperidol in the plasma and blood of patients on depot haloperidol.
Psychopharmacology (Berl). 1992;106(2):268-74. doi: 10.1007/BF02801983.
6
Haloperidol reductase in human and guinea pig livers.人类和豚鼠肝脏中的氟哌啶醇还原酶
Drug Metab Dispos. 1989 May-Jun;17(3):330-3.
7
Haloperidol reductase activity in red blood cells from oriental patients on haloperidol.服用氟哌啶醇的东方患者红细胞中的氟哌啶醇还原酶活性。
Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(2):275-8. doi: 10.1016/0278-5846(91)90092-f.
8
Ketone reductase activity and reduced haloperidol/haloperidol ratios in haloperidol-treated schizophrenic patients.
Psychiatry Res. 1995 Jul 28;57(2):101-8. doi: 10.1016/0165-1781(95)02633-8.
9
[Value of the determination of erythrocyte haloperidol ketone reductase activity in the evaluation of haloperidol therapy].[红细胞氟哌啶醇酮还原酶活性测定在氟哌啶醇治疗评估中的价值]
Therapie. 1994 Jan-Feb;49(1):71-4.
10
[Erythrocyte ketone reductase activity, total plasma haloperidol and acute psychoses].[红细胞酮还原酶活性、血浆总氟哌啶醇与急性精神病]
Encephale. 1995 Nov-Dec;21(6):417-24.

引用本文的文献

1
Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients.在韩国精神分裂症患者中，低剂量而非高剂量的氟哌啶醇血浆浓度与CYP2D6基因型相关。
Br J Clin Pharmacol. 2001 Sep;52(3):265-71. doi: 10.1046/j.0306-5251.2001.01437.x.
2
Pharmacokinetics of haloperidol: an update.氟哌啶醇的药代动力学：最新进展。
Clin Pharmacokinet. 1999 Dec;37(6):435-56. doi: 10.2165/00003088-199937060-00001.
3
Effect of quinidine on the interconversion kinetics between haloperidol and reduced haloperidol in humans: implications for the involvement of cytochrome P450IID6.
奎尼丁对人体内氟哌啶醇与还原型氟哌啶醇相互转化动力学的影响：细胞色素P450IID6参与的意义
Eur J Clin Pharmacol. 1993;44(5):433-8. doi: 10.1007/BF00315539.
4
Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase).还原型氟哌啶醇氧化为氟哌啶醇：人P450IID6（司巴丁/异喹胍单加氧酶）的作用。
Br J Clin Pharmacol. 1991 Jun;31(6):655-60. doi: 10.1111/j.1365-2125.1991.tb05588.x.
5
Reduced haloperidol: a factor in determining the therapeutic benefit of haloperidol treatment?氟哌啶醇用量减少：决定氟哌啶醇治疗疗效的一个因素？
Psychopharmacology (Berl). 1992;106(3):289-96. doi: 10.1007/BF02245407.
6
Determination of haloperidol and reduced haloperidol in the plasma and blood of patients on depot haloperidol.
Psychopharmacology (Berl). 1992;106(2):268-74. doi: 10.1007/BF02801983.